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Phenobarbital Compared with Phenytoin for the Treatment of Neonatal Seizures NEJM 341:485-489, Painter,M.J.,et al, 1999 See this aricle in Pubmed Article Abstract Seizures were controlled in 13 of the 30 neonates assigned to receive phenobarbital (43 percent) and 13 of the 29 neonates assigned to receive phenytoin (45 percent; P=1.00). when combined treatment is considered, seizure control was achie ved in 17 (57 percent) of the neonates assigned to receive phenobarbital first and 18 (62 percent) of those assigned to receive phenytoin first (P=0.67). The severity of the seizures was a stronger predictor of the success of treatment than was the assig ned agent. Neonates with mild seizures or with seizures that were decreasing in severity before treatment were more likely to have their seizures end, regardless of the treatment assignment. Phenobarbital and phenytoin are equally but incompletely effec tive as anticonvulsants in neonates. With either drug given alone, the seizures were controlled in fewer than half of the neonates.

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(click to filter results - removes previous filter) anticonvulsants anticonvulsants,effectiveness dilantin phenobarbital prognosis review article seizure seizure,neonatal seizure,treatment of treatment of neurologic disorder

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